Endocrine Abstracts

The ingestion of high-fat diet has been considered a crucial factor in the genesis of subclinical systemic inflammation and insulin resistance. The resistance training (RTr) can be an effective tool for the prevention and treatment of immune-metabolic disorders through physiological and morphological adaptations. The purpose of the present study was to analyze the effects of RTr and cessation of training on muscle inflammation and expression of genes related to glucose metabol...

Introduction: A precisely measured corticoid level is important for decision-making in daily clinical practice. These levels can be influenced in the pre-analytical phase, when the effect of stress, timing, and diet can be important.The aim of this study was to elucidate optimal conditions for blood sampling as well as the choice of analytical methods, which they will be used in measuring of corticoids.Methods: By studying ten wome...

Both metabolism and cardiac function fluctuate over the course of the day according to energy supply and demand. The triiodothyronine (T3) regulates several genes related to metabolism and function in cardiomyocytes. Our previous data have suggested that there is a potential interrelationship between the regulation of cardiac function by T3 and the intrinsic circadian clock in the heart. Considering that: i) the hypothyroidism is associated to a reduction...

Introduction: Hereditary medullary thyroid carcinoma (MTC) is associated with only one major cause – germline mutations in the RET proto-oncogene. The most of tested families with MTC is related to specific RET mutation, however, very small number of families left unresolved without the causing inherited mutation. New techniques of next generation sequencing give hope in finding the new candidate genes that could be involved in the pathogenesis of these ...

The anterior pituitary gland occupies a central position in the hypothalamus–pituitary glands axes and secretes hormones involved in reproduction, growth, and metabolism. The plasma concentrations of pituitary hormones present fluctuations during the 24 h and are markedly altered during the hypothyroidism. The presence of an intra-pituitary circadian oscillator might be related to these oscillations; however, the molecular mechanism and the consequences of the hypothyroid...

TSH is the main regulator of the thyroid hormones (THs) synthesis/secretion, which in turn exert a negative feedback mechanism on the Tshb mRNA expression in the pituitary gland by reducing their transcription rate. Some of triiodothyronine (T3) effects are also shown in short period of time, characterizing the non genomic actions of THs. It has been shown previously that T3 acts on posttranscriptional steps of TSH synthesis and reduces its secre...

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth fa...

Insulin hypersecretion during oral or intravenous glucose tolerance test (OGTT, ivGTT) was described previously in women with polycystic ovary syndrome (PCOS). Little attention was given to the regulation of insulin secretion in these subjects. We aimed to study the secretion of incretins (glucose-dependent insulinotropic polypeptide, GIP, glucagon-like peptide 1, GLP-1), during OGTT in normoglucose-tolerant PCOS women.After signing written informed cons...

Aim: To examine the secretion of insulin and glucagon in PCOS in the context of insulin sensitivity.Patients and methods: 13 healthy women (BMI 21.8(2.2) kg/m2), 21 PCOS without family history of DM2 (FH-); BMI 24.3 (4.4) kg/m2 and 16 PCOS with the 1st degree relative affected by DM2 (FH+); BMI 26.7 (4.2) kg/m2. Euglyceamic hyperinsulinaemic clamp (1mIU kg−1.min−1; with the determination ...

Aim and background: Retinol binding protein 4 (RBP 4) is an adipocyte-secreted molecule causing insulin resistance in transgenic animals. RBP was increased in subjects with impaired glucose tolerance and diabetes type 2. The levels of RBP-4 in PCOS were not investigated till now.Subjects and methods16 lean PCOS (BMI 21.4 (1.75) kg/m2, age 24.1 (4.1) years), 25 obese PCOS (BMI 30.3 (4.8) kg/m2, age 26.3 (5.0) years) and 13 healthy wo...